[image: MOTS-C.jpg]
MOTS-C is a peptide derived from the mitochondria, the cellular powerhouse responsible for generating energy, and it has gained attention for its potential role in improving insulin sensitivity, promoting fat breakdown, and enhancing energy levels.
MOTS-C is a small, 16-amino acid bioactive peptide encoded within the mitochondrial DNA.
*It was discovered in 2015* <www.ncbi.nlm.nih.gov/pmc/articles/PMC9854231/#CR7>:
“In 2015, the MOTS-c peptide (mitochondrial open reading frame of the 12S rRNA type-c), encoded by mitochondrial DNA, was discovered. MOTS-c is mainly activated by stress and exercise, while its expression decreases with aging.
*MOTS*-*c **is an exercise mimetic, it *targets the folate cycle, leading to an accumulation of 5-aminomidazole-4-carboxamide ribonucleotide (AICAR) as well as AMPK activation. This in turns improves utilization of glucose (specifically to muscle), decreases insulin sensitivity, increases NAD+ production and promotes fat oxidation. Thus making your cells to be more efficient at utilizing all the substrates.
*Potential Benefits:*
–
Improved Insulin Sensitivity: particularly beneficial for individuals with insulin resistance, prediabetes, or type 2 diabetes. It can help manage blood sugar levels and reduce the risk of complications associated with these conditions. –
Enhanced Fat Breakdown (Lipolysis): MOTS-C exerts its influence on genes and cellular mechanisms involved in lipid metabolism, encouraging the body to use stored fat as an energy source. This can have a profound impact on weight management and body composition. –
Increased Energy Levels: MOTS-C’s role in optimizing mitochondrial function has a direct impact on energy production. Mitochondria are responsible for generating adenosine triphosphate (ATP), which serves as the primary energy currency of cells. This in turn can have wide range of positive effects on overall vitality and physical performance. –
Potential Longevity Benefits: While research is ongoing, the optimization of mitochondrial function and the regulation of metabolic processes by MOTS-C have led to speculations about its potential role in promoting longevity and healthy aging. –
Systemic Metabolic Regulation: MOTS-C’s impact extends beyond specific tissues or organs. It exerts systemic effects, contributing to the overall metabolic regulation of the body. It can influence adipose tissue, liver, and the cardiovascular system, potentially addressing various metabolic concerns and improving overall health. This is one of many reviews which highlight the *various benefits of MOTS-c described:* <pubmed.ncbi.nlm.nih.gov/36233287/>“Since MOTS-c has important cellular functions as well as a possible hormonal role, it has been shown to have beneficial effects on age-related diseases including Diabetes, Cardiovascular diseases, Osteoporosis, postmenopausal obesity and Alzheimer. Aging is characterized by gradual loss of (mitochondrial) metabolic balance, decreased muscle homeostasis and eventual diminished physical capability, which potentially can be reversed with MOTS-c treatment. This review examines the latest findings on biological effects of MOTS-c as a nuclear regulatory peptide and focuses on the role of MOTS-c in aging and age-related disorders, including mechanisms of action and therapeutic potential”
The discovery of MOTS-C and its role in mitochondrial-nuclear cross talk has led to intriguing implications in the field of biochemistry and cellular biology. It exemplifies how cellular components work together to ensure the efficient functioning of the entire organism. Furthermore, it opens up the possibility of leveraging MOTS-C’s regulatory properties for therapeutic purposes in the context of metabolic diseases and age-related conditions.
*Potential Side Effects*
Can deplete folate levels (it’s recommended to take methylated B-complex daily while taking MOTS-c), insomnia, hypoglycemia, injection site reaction.
MOTS-C is a peptide derived from the mitochondria, the cellular powerhouse responsible for generating energy, and it has gained attention for its potential role in improving insulin sensitivity, promoting fat breakdown, and enhancing energy levels.
MOTS-C is a small, 16-amino acid bioactive peptide encoded within the mitochondrial DNA.
*It was discovered in 2015* <www.ncbi.nlm.nih.gov/pmc/articles/PMC9854231/#CR7>:
“In 2015, the MOTS-c peptide (mitochondrial open reading frame of the 12S rRNA type-c), encoded by mitochondrial DNA, was discovered. MOTS-c is mainly activated by stress and exercise, while its expression decreases with aging.
*MOTS*-*c **is an exercise mimetic, it *targets the folate cycle, leading to an accumulation of 5-aminomidazole-4-carboxamide ribonucleotide (AICAR) as well as AMPK activation. This in turns improves utilization of glucose (specifically to muscle), decreases insulin sensitivity, increases NAD+ production and promotes fat oxidation. Thus making your cells to be more efficient at utilizing all the substrates.
*Potential Benefits:*
–
Improved Insulin Sensitivity: particularly beneficial for individuals with insulin resistance, prediabetes, or type 2 diabetes. It can help manage blood sugar levels and reduce the risk of complications associated with these conditions. –
Enhanced Fat Breakdown (Lipolysis): MOTS-C exerts its influence on genes and cellular mechanisms involved in lipid metabolism, encouraging the body to use stored fat as an energy source. This can have a profound impact on weight management and body composition. –
Increased Energy Levels: MOTS-C’s role in optimizing mitochondrial function has a direct impact on energy production. Mitochondria are responsible for generating adenosine triphosphate (ATP), which serves as the primary energy currency of cells. This in turn can have wide range of positive effects on overall vitality and physical performance. –
Potential Longevity Benefits: While research is ongoing, the optimization of mitochondrial function and the regulation of metabolic processes by MOTS-C have led to speculations about its potential role in promoting longevity and healthy aging. –
Systemic Metabolic Regulation: MOTS-C’s impact extends beyond specific tissues or organs. It exerts systemic effects, contributing to the overall metabolic regulation of the body. It can influence adipose tissue, liver, and the cardiovascular system, potentially addressing various metabolic concerns and improving overall health. This is one of many reviews which highlight the *various benefits of MOTS-c described:* <pubmed.ncbi.nlm.nih.gov/36233287/>“Since MOTS-c has important cellular functions as well as a possible hormonal role, it has been shown to have beneficial effects on age-related diseases including Diabetes, Cardiovascular diseases, Osteoporosis, postmenopausal obesity and Alzheimer. Aging is characterized by gradual loss of (mitochondrial) metabolic balance, decreased muscle homeostasis and eventual diminished physical capability, which potentially can be reversed with MOTS-c treatment. This review examines the latest findings on biological effects of MOTS-c as a nuclear regulatory peptide and focuses on the role of MOTS-c in aging and age-related disorders, including mechanisms of action and therapeutic potential”
The discovery of MOTS-C and its role in mitochondrial-nuclear cross talk has led to intriguing implications in the field of biochemistry and cellular biology. It exemplifies how cellular components work together to ensure the efficient functioning of the entire organism. Furthermore, it opens up the possibility of leveraging MOTS-C’s regulatory properties for therapeutic purposes in the context of metabolic diseases and age-related conditions.
*Potential Side Effects*
Can deplete folate levels (it’s recommended to take methylated B-complex daily while taking MOTS-c), insomnia, hypoglycemia, injection site reaction.
